Polymorphism in Alzheimer Aβ Amyloid Organization Reflects Conformational Selection in a Rugged Energy Landscape

Polymorphism in Alzheimer Aβ Amyloid Organization Reflects Conformational Selection in a Rugged Energy Landscape

Elongation dynamics of amyloid fibrils: a rugged energy landscape picture.

Protein amyloid fibrils are a form of linear protein aggregates that are implicated in many neurodegenerative diseases. Here, we study the dynamics of amyloid fibril elongation by performing Langevin dynamic simulations on a coarse-grained model of peptides. Our simulation results suggest that the elongation process is dominated by a series of local minimum due to frustration in monomer-fibril ...

Evolution in a rugged fitness landscape.

Kauuman's NK-model for genetic evolution and adaption is analysed for K = N ?1. In this case it describes adaptive walks on random tness landscapes, and its dynamics is equivalent to the Metropolis algorithm for Derrida's Random Energy Model at zero-temperature. We derive analytical expressions for the average length and duration of adaptive walks, and for the variance about these averages. The...

Illusions of Significance in a Rugged Landscape

A great deal of academic research, particularly in the social sciences, makes an implicit assumption that the processes being investigated are largely decomposable, meaning that the effects of individual variables identified in one context are likely to be observed in other contexts as well. Many of the statistical tools employed in analyzing social science data, such as regression and structur...

Self-Organization in Models of Populations with Two-Parent Reproduction on a Rugged Fitness Landscape

The two-parent reproduction model of Derrida and Peliti is simulated on a rugged tness landscape. Fixed tness values for each possible genotype are assigned randomly, with all t individuals having the same probability of reproduction. The previously observed transition to a self-organized state of the population with less recombinational load, implies an abrupt change of genetic overlap distrib...